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GOUT Gout is an arthritic condition (inflammation of the joints) that mostly affects men age 40 and older. It is nearly always associated with chronic hyperuricemia , a long-lasting abnormally high concentration of uric acid in the blood. Metabolism of Purines. The process leading to hyperuricemia and gout begins with the metabolism of purines , which are nitrogen-containing compounds that are important for energy. Purines can be divided into two types: Endogenous. Endogenous purines are manufactured within human cells. Exogenous. Exogenous purines are obtained from foods. All mammals except humans possess an enzyme called uricase that breaks purines down into a very soluble product called allantoin . Without uricase, purine ultimately breaks down into uric acid , which can build up in body tissues if it is not adequately eliminated in urine. Uric Acid and Hyperuricemia. Uric acid is produced in the liver and enters the bloodstream. The path leading to h...
Epilepsy in children is considered as one of the most prevalent neurological condition which also affects the adult population to a great extent. It is marked by the occurrence of chronic seizures in a child without any provocation. These seizures take place due to excessive and abnormal neuronal activities in a child’s brain. Epileptic seizures can be controlled by proper medication though complete cure may not be achieved. The good thing is that some variants of this syndrome are only limited to the childhood of a person. Epilepsy, as a matter of fact, should be understood as a group of syndromes with various symptoms. However all of them are linked with irregular electric activity that takes place in the brain of the victim. This can occur to a child anytime after his or her birth. On an average estimate, this menace can affect one in every 200 children. It happens in children even in the developed nations. In fact epilepsy in children is quite a common disorder which requires immed...